To understand what role an individual gene plays, biologists have, for 100 years, been using a trick of nature: While in principle, the genome in all cells of an organism is the same, mutations arise in individual cells. These mutations differentiate a cell from its neighbors, forming a ‘genetic mosaic.” Now, Simon Hippenmeyer, Professor at IST Austria, has advanced genetic mosaic analysis, making almost all genes in the mouse genome accessible to single-cell genetic mosaic analysis.
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Source: Phys.org