Deep space is most likely going to be humanity’s final frontier, and space travel will undoubtedly become much more common in the future. However, space is a very hostile environment not only because of the technical difficulties that entail going there, but also because of the detrimental effects that constant microgravity has on the human body. Some examples of these are bone loss, muscle atrophy, and liver and kidney problems, as well as space motion sickness.
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Source: Phys.org