Extracellular vesicles (EVs) are highly involved in the progression of diverse diseases. Therefore, targeting EV biogenesis is a potential strategy for the treatment of the related diseases, which urges an improved understanding of EV biogenesis. During the biogenesis of EV subset, exosomes, invagination of the plasma membranes forms early endosomes which mature into late endosomes and multivesicular bodies (MVBs) eventually. MVBs fuse with not only the plasma membranes to release EVs but also lysosomes for degradation. Rab7 participates in the lysosomal targeting of MVBs. However, the proteins on MVB that directly bind Rab7, causing MVB recruitment of Rab7 remain unidentified.
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Source: Phys.org