New details behind how the Shigella pathogen delivers bacterial proteins into our cells

Shigella, a bacterial pathogen that causes dysentery and is the leading cause of childhood diarrheal diseases, inserts a pore called a translocon into an infected person’s intestinal cells and then injects bacterial proteins into the cells. There, the proteins hijack the cells’ machinery to help Shigella multiply. In a study published in mBio, a team at Massachusetts General Hospital (MGH) has uncovered important details about Shigella’s translocon, which may help researchers develop an effective strategy to block this critical component of infection.


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Source: Phys.org