In order to cause disease, the human pathogen Staphylococcus aureus must adapt to the changing host environment. Many of these adaptations are mediated through two-component signal transduction systems (TCSs) that coordinate gene expression in response to environmental stimuli. In a new study reported in the Journal of Bacteriology, researchers at Illinois provide insight into the signal transduction mechanism utilized by the staphylococcal TCS ArlRS in response to host-imposed manganese and glucose starvation.
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Source: Phys.org