Within complex tissues such as cancer tumors, individual cells can vary widely from each other. Internally, cancer cells can develop unique DNA mutations and genomic changes, potentially leading to drug resistance, metastasis, or relapse. Externally, the cells’ specific locations within the tissue also matter, since the local structure of a tumor and its surrounding tissues can affect cell state and drug permeability.
Click here for original story, New DNA sequencing technique preserves cells’ locations within tissues
Source: Phys.org