Cytochrome P450, family 17, subfamily A, polypeptide 1 (cyp17a1) is a critical enzyme involved in gonadal steroidogenesis, including androgen and estrogen production. Among sex steroids, androgen signaling disruption is known to cause testicular malformation and defective spermatogenesis in zebrafish. Interestingly, enhanced spermatogenesis has been observed in cyp17a1-deficient zebrafish and common carp, with the impaired process of the androgen production.
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Source: Phys.org