Thyroid hormone (TH) plays a multifunctional role in metabolism and development in vertebrates. The synthesis and secretion of TH is determined by the hypothalamus-pituitary-thyroid (HPT) axis. The tripeptide thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2) is the initial hormone of HPT, synthesized in the hypothalamus and acts on TRH receptor (TRHR). Upon stimulation by TRH, TRHR prompts thyroid stimulating hormone (TSH, thyrotropin) production, which then induces the synthesis of TH.
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Source: Phys.org