Transferring the nuclear genome from one egg into the cytoplasm of a donor egg is a strategy to enable women carrying mutations in their mitochondrial DNA to have healthy babies. A new study from Wei Shang of Chinese PLA General Hospital, Beijing, Fuchou Tang of Peking University, Beijing, and colleagues, publishing August 16 in the open-access journal PLOS Biology, uses multiple “omics” techniques to show that this strategy, called spindle transfer, is likely to be safe, with little evidence of genetic or functional difference between the resulting embryos and healthy control in vitro fertilization (IVF) embryos. The results are likely to spur further adoption of spindle transfer for IVF when there is a risk of mitochondrial disease.
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Source: Phys.org