New understanding of how faulty metabolism triggers adrenal cancer

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands. This discovery explains how impaired metabolism due to mutations in a key enzyme called succinate dehydrogenase B disables a normal bioenergetic sensing mechanism, triggering cells to divide uncontrollably.


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Source: ScienceDaily