A research team led by Prof. Zhao Guoping from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) has proposed a mechanism by which protein disulfide isomerase (PDI) can translocate from endoplasmic reticulum (ER) to the mitochondria under radiation stimulation, participate in regulating mitophagy and mediate tumor radiosensitivity, which is of great significance for understanding the role of mitochondrial targets in radiosensitivity.
Click here for original story, Protein disulfide isomerase regulates radio sensitivity by mitophagy
Source: Phys.org