In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria. Many species of pathogenic bacteria have transmissible antibiotic resistance plasmids, which are often reproduced through a rolling circle replication machinery. Plasmid pMV158, which is present in the genus Streptococcus, belongs to this group. This plasmid determines resistance to tetracycline and its replication is initiated by the RepB protein.
Click here for original story, A protein structure reveals how replication of DNA coding for antibiotic resistance is initiated
Source: Phys.org