Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the structure of messenger RNA–based medicines. They can elucidate mRNA sequences while quantifying “capping” at one end of the molecule and the integrity of the tail on the other, all vital in mRNA pharmaceuticals. The method is a crucial innovation for quality control in production lines.
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Source: Phys.org