New antitubercular drugs are vital due to the spread of resistant strains of Mycobacterium tuberculosis. A research team from Skoltech, MIPT, and the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus (IBOCH NAS) has obtained ultra-high-resolution structures of the M. tuberculosis cytochrome in complex with an inhibitor. The team’s findings show that glycerol—a widely used additive to protein solutions—can compromise structural-functional studies and hinder drug development. The research was published in Acta Crystallographica Section D Structural Biology.
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Source: Phys.org