Cyclic peptides often exhibit low membrane permeability that can be significantly improved via amide-to-ester substitutions, as demonstrated by researchers from Tokyo Institute of Technology (Tokyo Tech). The utilization of substitutions shown in a new study can be used to develop cyclic peptides with high membrane permeability and oral bioavailability for clinical and therapeutic applications.
Click here for original story, Investigating the effects of amide-to-ester substitutions on membrane permeability of cyclic peptides
Source: Phys.org