An international collaboration between two Danish and two German teams has delineated that the so-called “Arsenite resistance 2 (ARS2)” protein is capable of inducing early transcription termination by recruiting the termination factors ZC3H4/WDR82 via a conserved protein-protein interaction. In turn, it was found that ZC3H4 associates with the “nuclear exosome targeting (NEXT)” complex, providing access to the nuclear RNA degradation machinery.
Click here for original story, New connection between early transcription termination and RNA turnover
Source: Phys.org