Meiotic recombination-related gene (e.g., DMC1, HFM1, MEIOB, MAJIN, C14ORF39/SIX6OS1, STAG3, SYCE1, SYCP2-3, TERB1-2) mutations have been identified in human subfertility or infertility. Surprisingly, most patients have been found to have aberrant splicing of genes such as MEIOB, C14ORF39/SIX6OS1, STAG3, and SYCE1. Therefore, it is imperative to understand the mechanism of alternative splicing (AS) and its role in human reproduction to provide new insights for clinical diagnosis.
Click here for original story, Scientists identify gene crucial for male meiosis during homologous pairing and synapsis
Source: Phys.org