Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similarities, and are essential for their interactions and functions.
Click here for original story, Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein
Source: Phys.org