The emergence of antibiotic-resistant bacteria poses a significant threat to human health, both on Earth and in space. Common, harmless bacteria like Enterococcus faecalis (EF) and Enterococcus faecium, can be found on the International Space Station just as they are on Earth — and yet, they exhibit resistance to antibiotics and are hardier than their counterparts down on the ground. This raises concerns about potential more harmful bacteria causing infections for astronauts, especially during long-duration missions, as standard antibiotic treatments might prove ineffective.