Protein complex FACT able to unwind nucleosomes without expending energy

A group of researchers from the Institute of Bioorganic Chemistry of the RAS and Moscow State University, in collaboration with the University of Utah, has for the first time successfully made use of the FRET microscopy method to demonstrate the ability of nucleosomes to reversibly unwind under the action of FAST without expending any energy. The data obtained will illuminate the role this protein complex plays in actively dividing cells in tumor tissues. The results were published in Nature Structural & Molecular Biology.