So far, Denisovans were only known from a small collection of fossil fragments from Denisova Cave in Siberia. A research team now describes a 160,000-year-old hominin mandible from Xiahe in China. Using ancient protein analysis, the researchers found that the mandible’s owner belonged to a population that was closely related to the Denisovans from Siberia. This population occupied the Tibetan Plateau in the Middle Pleistocene and was adapted to this low-oxygen environment long before Homo sapiens arrived in the region.