In a study published in Nature on June 10, researchers from Dr. Yang Hui’s Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational Biology of CAS and Sichuan University demonstrated that DNA base editors generated tens of thousands of off-target RNA single nucleotide variants (SNVs) and these off-target SNVs could be eliminated by introducing point mutations to the deaminases.
Click here for original story, DNA base editing induces substantial off-target RNA mutations
Source: Phys.org