CRF1R and CRF2R, two members of class B G-protein-coupled receptors (GPCRs), are widely expressed in the central and peripheral nervous systems and activated by the corticoliberin family of peptide hormones that include CRF and urocortins 1-3 (UCN1-UCN3). The active receptors function as a key mediator of endocrine, autonomic, behavioral, and immune responses to stress by coupling to G protein (Gs).
Click here for original story, Research: Structural and functional studies of corticotropin-releasing factor receptors
Source: Phys.org