Jean and Peter Medawar wrote in 1977 that a virus is “simply a piece of bad news wrapped up in proteins.” The ‘bad news’ in the SARS-CoV-2 case is the new coronavirus carries its mysterious genome in the form of a very long ribonucleic acid (RNA) molecule. Grappling with COVID-19 pandemic, the world seems to be lost with no sense of direction in uncovering what this coronavirus (SARS-Cov-2) is composed of. Being an RNA virus, SARS-Cov-2 enters host cells and replicates a genomic RNA and produces many smaller RNAs (called ‘subgenomic RNAs’). These subgenomic RNAs are used for the synthesis of various proteins (spikes, envelopes, etc.) that are required for the beginning of SARS-Cov-2 lineage. Thus, the smaller RNAs make good targets for interfering with the new coronavirus’s conquering of our immune system. Though recent studies reported the sequence of the RNA genome, they only predicted where their genes might be, leaving the world still drowning in disorientation.
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Source: Phys.org