By systematically analyzing epigenetic changes in angiogenesis-stimulated vascular endothelial cells, Professor Takashi Minami (Kumamoto University, Japan) and his team have found a unique epigenetic modification (bivalent histone-mark switch) specific to critical transcription factors that induce genes essential for angiogenesis and revealed that the histone modifiers responsible for this modification are vital for postnatal angiogenesis.
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Source: Phys.org