The initiation of the innate immune responses relies on the detection of microbes by multiple pattern recognition receptors. Among these receptors, cyclic GMP-AMP synthase (cGAS) has been identified as a major and universal cytosolic DNA sensor that is independent of specificity of DNA sequence and/or cell type. However, previous studies have suggested that the binding affinity of cGAS to DNA is relatively low, how the low binding affinity between cGAS and DNA still efficiently mediates the innate immune responses remains largely unknown.
Click here for original story, Researchers identify Ku proteins as new co-sensors of cyclic GMP-AMP synthase
Source: Phys.org