Study reveals ERK activity is a molecular switch between scarring and tissue regeneration

Why do some animals regenerate lost tissues after injury while others don’t? Researchers from the lab of Kerstin Bartscherer (Osnabrück University and formerly Hubrecht Institute) and Ashley Seifert (University of Kentucky) studied spiny mice, which have a remarkable regenerative capacity, to answer this question. They compared and modulated the injury responses of these mice and common laboratory mice, that show scarring upon injury. This revealed that ERK signaling is a crucial molecular switch between scarring and regeneration.


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Source: Phys.org