The extent and depth of lakes in glaciated regions of North America are controlled by climate and the influence of differential isostatic rebound of the land’s surface that began when Pleistocene ice melted from the continent. This relationship and the post-glacial history of Lake of the Woods—one of the largest lake complexes in North America and the source of water for the city of Winnipeg—is presented for the first time in a new study by five Canadian researchers.