Although much scientific research has been done into the development of the skeleton, the underlying mechanisms that drive the formation and maintenance of bones are still not very well understood, and research into the development of bone remains of enormous importance. To date, 20 percent of women at the age of 65 years develop osteoporosis, and 40 percent of elderly men suffering a hip fracture die within the year during the recovery. Skeletal diseases are still among the most frequent syndromes in Western population that result in high mortality, urging scientists to research into better cures.