Proteins are like machines. For some diseases, it can be useful to turn these machine off or on when they are too active or not active enough. One way to control switching in a protein, such as a nuclear receptor, is to put a drug “in the pocket” of the drug. For her Ph.D. research, Iris van de Gevel looked at controlling two receptors: RORγt, a receptor that is overactive in autoimmune diseases like rheumatoid arthritis and psoriasis, and PPARγ, a receptor that plays an important role in type 2 diabetes.
Click here for original story, Controlling the nuclear receptors of proteins associated with diseases
Source: Phys.org